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9th May 2012 @ 07:26
Resolution of MNR26-1 with (+)-dibenzoyl-D-tartaric acid (MNR5-1)

MNR30-1%20scheme.png

mnr30-1%20table.PNG

Hazard and Risk Assessment:
As for MNR2-1

MNR26-1 (0.40 g, 1.52 mmol) and MNR5-1 (0.586 g, 1.52 mmol) was dissolved in IPA (4 mL) with heating and water (1 mL) was added. All the reagents went into solution and the mixture was left to stand overnight. No crystals grew over night, IPA (2 mL) was added and mixture allowed to stand for another 8 hours. Again, no crystals grew, hexane (3 mL) was added and mixture left overnight. Some crystals grew and the mixture was left to stand over the weekend. Crystals were washed with IPA:Hex:water (6:3:1) and dried to give fine white crystals which were dried under vacuum for 6 hours.

Salt recovered 0.295 g