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17th April 2012 @ 09:06

Hazard and Risk Assessment:

rac-MNR11-13 (2.00 g, ) was dissolved in a mixture of EtOH (10 mL) and 1M HCl (50 mL) and heated to reflux for 14 h. The solution was allowed to cool to room temperature then cooled in an ice bath, basified with NaOH to pH 12-13 and extracted with DCM (4 x 50 mL). The organic fractions were combined, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give a light brown solid.

0.437 g

Very low yield, extracted with EtOAC

0.062 g

total recovered

0.499 g, 35 %

The pH of the aqueous layer was taken to 6 by the addition of conc HCl and extracted with EtOAc