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6th May 2012 @ 16:14
Spectroscopic Method: HPLC
Substituent: Nitro
HPLC Chromatogram of (3E)-3-(4-Nitrobenzylidene)-1,3-dihydro-2H-indol-2-one:

HPLC Chromatogram of (3E)-3-(4-Nitrobenzylidene)-1,3-dihydro-2H-indol-2-one


The sharp peak at the retention time of 6.074 confirms the presence of a single isomer in this compound while the small peak at 5.832 retention time indicates trace of impurities. The percentage area peak of this compound confirms its percentage yield to be 67.58% against its calculated value of 70%.
Attached Files
6th May 2012 @ 16:11
Spectroscopic Method: HPLC
Substituent: Methoxy
HPLC Chromatogram of (3E)-3-(4-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one:

HPLC Chromatogram of (3E)-3-(4-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one


The High Performance Liquid Chromatography chromatogram of (3E)-3-(4-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one shows a single sharp peak at 5.956 retention time which confirms that a single isomer has been isolated in this compound. The peaks at 3.600 and 6.794 retention times are due impurities. The percentage area peak of this single isomer confirms the percentage yield of this compound to be 64.53% which is in line with the calculated percentage yield of 65%.
Attached Files
6th May 2012 @ 16:07
Spectroscopic Method: HPLC
Substituent: Bromo
HPLC Chromatogram of (3E)-3-(4-Bromobenzylidene)-1,3-dihydro-2H-indol-2-one:

HPLC Chromatogram of (3E)-3-(4-Bromobenzylidene)-1,3-dihydro-2H-indol-2-one


The two sharp peaks at 6.876 and 7.388 retention times confirm the presence of (E)- and (Z)- isomers of (3E)-3-(4-Bromobenzylidene)-1,3-dihydro-2H-indol-2-one while the two speaks at 3.596 and 4.715 retention times are due to impurities. The percentage yields of these two isomers (E) - and (Z) - are 12% and 42% respectively.
Attached Files
6th May 2012 @ 16:04
Spectroscopic Method: HPLC
Substituent: Chloro
HPLC Chromatogram of (3E)-3-(4-Chlorobenzylidene)-1,3-dihydro-2H-indol-2-one:

HPLC Chromatogram of (3E)-3-(4-Chlorobenzylidene)-1,3-dihydro-2H-indol-2-one


The two major sharp peaks at 6.396 and 6.788 retention times confirm the presence of two isomers (E and Z)- in this compound, (3E)-3-(4-Chlorobenzylidene)-1,3-dihydro-2H-indol-2-one, while the small peak at 4.212 retention time is due to the presence of impurities. The areas of these two isomers are 23.9136% and 75.5619% which suggest that their percentage yield are 18% and 57% for (E)- and (Z)- isomers respectively since their total percentage yield is 75%.
Attached Files
27th March 2012 @ 11:25
Spectroscopic Method: HPLC
Substituent: Methyl
HPLC Chromatogram of (3E)-3-(4-Methylbenzylidene)-1,3-dihydro-2H-indol-2-one:

HPLC Chromatogram of (3E)-3-(4-Methylbenzylidene)-1,3-dihydro-2H-indol-2-one


The sharp peak at 6.298 retention time confirms the presence of single isomer in this compound while the peaks at retention times 3.595 and 4.158 are due to the presence of impurities. The percentage yield of this compound is 68.40% against the calculate value of 69.5%
Attached Files