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23rd April 2013 @ 07:48
Mnr: 21-30
Resolution of MNR26-7 with (-)-dibenzoyl-L-tartaric acid (MNR6-1) to obtain MNR27-26

Starting material from
Hydrolysis of MNR11-18 to give MNR26-7
Synthesis of (-)-Dibenzoyl-L-tartaric acid (MNR6-1)

MNR27-1%20scheme.png



Hazard and Risk Assessment:
As for MNR2-1

MNR26-7 (0.10 g, 0.39 mmol) and (-)-dibenzoyl-L-tartaric acid. 2IPA (0.148 g, 0.39 mmol) was dissolved in a mixture of isopropanol (1.6 mL) and water (0.2 mL). The reagents went into solution with minimal heating and we left to stand at room temperature overnight. No crystals appeared overnight for the mixture was transferred to the freezer,the mixture became a gel so IPA (1mL) was added and the mixture was left to stand overnight. No crystals formed - the reaction was not taken any further.