All Notebooks | Help | Support | About
25th August 2011 @ 05:26
Multigram-scale racemic resolution of praziquanamine with (-)-Dibenzoyl-L-tartaric acid (MW49-13)
MW49-13 [α]D20 = +146.2° (c=1, DCM)
100% ee ->[α]D20 = +296° (c=1, DCM)
-> ee = 146.2/296
-> ee = 49%

N-Cyclohexanoyl-protection of the enantiopure R-(-)-PZQamine in a multigram scale (MW48-4)
MW48-4 [α]D20 = -135.0° (c=1, EtOH)
100% ee ->[α]D20 = -139° (c=1, EtOH)

-> ee = -135.0/-139
-> ee = 98%

-> No change since original calculation therefore R-PZQ is stable stored at 5°C for at least 10 months.