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2nd February 2014 @ 22:25
START: 31/01/14
FINISH:


Scheme
scheme_KAB120.png

Hazard and Risk Assessment

Previous Experiments
Synthesis of (-)-Dibenzoyl-L-tartaric acid (MNR6-1)
Hydrolysis of KAB8-17 (to give KAB119-1)

Data Table
DataTable.png


Procedure
resolution1.png
31/01/14. Amounts used are described in the table above. The mixtures of KAB119-1 and MNR6-1 were suspended in IPA and water (with heat gun heating). If relevant, the additional solvent was added. The vials were sealed and stored in the dark at rt over the weekend.
Samples 31/01/14

03/02/14. No crystals formed. The mixtures were concentrated under reduced pressure. Second attempt: X.

Vial 2 was dissolved in 1:1, water:IPA, v/v (4 mL) and allowed to stand at rt. The clear yellow mixture turned into a gel. Water (4 mL) was added. The mixture was sonicated until a heterogenous yellow suspension. Isopropanol was added slowly. Sealed vial. The clear yellow solution at rt overnight.

04/02/14.
Vial 2 = crystals
Combined remainder. Dried in vacuo. Total X g.
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NOTES: IPA = 2-propanol
Attached Files
Scheme KAB120-1
Samples 31/01/14
No crystals 03/02/14
KAB120-X Table1
KAB120-X Data Table