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5th June 2012 @ 11:47
Test reaction to see if crude MNR11-16 can be hydrolysed cleanly to MNR26-4




Hazard and Risk Assessment:
HIRAC MNR7.pdf


Procedure:
MNR11-16 ( 0.40 g, 1.07 mmol) was dissolved in a mixture of EtOH (2 mL) and 1M HCl (10 mL) and heated to reflux for 14 h. The solution was allowed to cool to room temperature then cooled in an ice bath, basified with NaOH to pH 12-13 and extracted with DCM (4 x 15 mL). The organic fractions were combined, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give a
Attached Files
mnr26-4 table.PNG
MNR26-4 scheme.png