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21st February 2012 @ 06:58
Mnr: 21-30
Screening conditions for optimum resolution of MNR26-1 with (-)-dibenzoyl-L-tartaric acid (MNR6-1) to obtain R-di-methoxy-PZQamine (MNR27-x)

* As a result of mnr27-1 not working.

MNR27-1%20scheme.png

mnr27-1%20table.PNG

Hazard and Risk Assessment:
As for MNR2-1

MNR27-2

MNR26-1 (0.08 g, 0.3 mmol) and (-)-dibenzoyl-L-tartaric acid. 2IPA (0.15 g, 0.3 mmol) was dissolved in isopropanol (4 mL) in a vial and heated with the heat gun to dissolve the reagents.

Everything went into solution and the vial was left to stand at room temperature overnight.


MNR27-3

MNR26-1 (0.08 g, 0.3 mmol) and (-)-dibenzoyl-L-tartaric acid. 2IPA (0.15 g, 0.3 mmol) was dissolved in hexane (4 mL) in a vial and heated with the heat gun to dissolve the reagents.

very little went into solution and the vial was left to stand at room temperature overnight.

MNR27-4

MNR26-1 (0.08 g, 0.3 mmol) and (-)-dibenzoyl-L-tartaric acid. 2IPA (0.15 g, 0.3 mmol) was dissolved in IPA (1 mL) ans hexane(3 mL) in a vial and heated with the heat gun to dissolve the reagents.

very little went into solution and the vial was left to stand at room temperature overnight.
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