Notice: Undefined index: inline in /home/www/hosts/www.ourexperiment.org/docs/export/xml.php on line 68

Notice: Undefined index: inline in /home/www/hosts/www.ourexperiment.org/docs/export/xml.php on line 68
15211522Hydrolysis of rac-PZQ (MW2-14)
Experiments
profiles.google.com-micha.wolfleMichael Wolfle
See: Hydrolysis of rac-PZQ (MW2-13)
Following the optimized conditions for rac-PZQ: see Optimizing the acid cleavage conditions II

MW2-13.png


Hazard and Risk Assessment:
Data: HIRAC MW2

Start time: 6:30 PM 24/01/2011
End time: 8:50 AM 25/01/2011

Procedure:
rac-PZQ (20.0 g, 64.0 mmol) was dissolved in a mixture of EtOH (150 mL) and 1N HCl (600 mL, 53.0 mL of 11.3 N HCl solution (35%) in 547 mL water) and heated to reflux for 14 h. Reaction monitored by TLC showed a complete consumption of PZQ (TLC, EA/hexane 1:1, Rf = 0.15 for PZQ).

Work-up:
Solution was cooled to room temperature, washed with EtOAc (4 times 15 mL), basified with NaOH solution (5 N) to ph 12, extracted with DCM (5 x 30 mL), washed with brine, dried over NaSO4, evaporated under reduced pressure.
pale yellow oil turned into a solid after freezing the oil with liquid nitrogen under high vac and warmed to room temperature.

Yield:
11.1 g (52.0 mmol, 86%) pale yellow solid
[M.W. = 202.1 g/mol]
m.p. = 116.5 - 118.5°C
Linked Entries
]]>2011-01-24T06:58:29+00:002011-01-25T04:41:39+00:00944fa07a709bd4a8f66d096e70f380a51http://www.ourexperiment.org/uri/fehttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.htmlhttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.htmlhttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xmlhttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.pnghttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=1521https://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=1522https://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=7152
15217152Hydrolysis of rac-PZQ (MW2-14)
Experiments
profiles.google.com-micha.wolfleMichael Wolfle
See: Hydrolysis of rac-PZQ (MW2-13)
Following the optimized conditions for rac-PZQ: see Optimizing the acid cleavage conditions II

MW2-13.png


Hazard and Risk Assessment:
Data: HIRAC MW2

Start time: 6:30 PM 24/01/2011
End time: 8:50 AM 25/01/2011

Procedure:
rac-PZQ (20.0 g, 64.0 mmol) was dissolved in a mixture of EtOH (150 mL) and 1N HCl (600 mL, 53.0 mL of 11.3 N HCl solution (35%) in 547 mL water) and heated to reflux for 14 h. Reaction monitored by TLC showed a complete consumption of PZQ (TLC, EA/hexane 1:1, Rf = 0.15 for PZQ).

Work-up:
Solution was cooled to room temperature, washed with EtOAc (4 times 15 mL), basified with NaOH solution (5 N) to ph 12, extracted with DCM (5 x 30 mL), washed with brine, dried over NaSO4, evaporated under reduced pressure.
pale yellow oil turned into a solid after freezing the oil with liquid nitrogen under high vac and warmed to room temperature.

Yield:
11.1 g (52.0 mmol, 86%) pale yellow solid
[M.W. = 202.1 g/mol]
m.p. = 116.5 - 118.5°C
Linked Entries
]]>2011-01-24T06:58:29+00:002015-06-19T04:46:02+01:009http://www.ourexperiment.org/uri/fehttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.htmlhttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.htmlhttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xmlhttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.pnghttps://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=1521https://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=1522https://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=7152https://www.ourexperiment.org/racres_pzq/1521/Hydrolysis_of_racPZQ_MW214.xml?revision=-1