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5th August 2012 @ 23:55
Repeating the reaction at standard conditions (25 °C over 1 hour) to see if the Yb(OTf)3 is stable enough to be stored in solution.

MNR41-4%20scheme.png
mnr41-8%20table.PNG

To a solution of MNR42-1 (0.2 g, 0.64 mmol) in dry acetonitrile (20 mL, HPLC grade stored over 3 Å molecular sieves for 24 hours) and 3 Å molecular sieves (3 g, dried in microwave) under argon at 0 °C, was added was added acetyl chloride (0.08 mL, 1.15 mmol), 2,6-lutidine (0.10 mL, 0.89 mmol, stored over 3 Å molecular sieves) and PZQ (0.02 g, 0.06 mmol). Yb(OTf)3 solution (0.128 g, in THF (15 mL)) (2.3 mL, 0.02 g, 0.03 mmol) was added and the reaction was stirred at 25 °C for 1 hour.
Attached Files
mnr41-10_1hour.pdf