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Pictet-Spengler route to Praziquantel
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27th July 2012 @ 02:35 Edited by www.google.com-accounts-
Edit Reason: corrected
Key:070179fdb69c2b6f8377e7245ea82598
27th July 2012 @ 02:32 Edited by www.google.com-accounts-
Edit Reason: First Entry
Key:d938d13f530278f594fbb3d234d0e9bd
Comments
Re: Yb(OTf)3/BINOL catalysed asymmetric acyl-PS formation of KAB26-20 by Murray Robertson
30th July 2012 @ 02:51
On the Monday morning - 4 days after the solution was made up - the flask that contained the Yb(OTf)3/BINOL mixture in THF had reduced in volume due to evaporation (flask still sealed with a septum) and nice, clear square pyramidal crystal had formed.

From%20KAB26-20%20-%20Yb%28OTf%293BINOL%

Washing with hexane (4 mL) caused slight precipitation so the mixture was washed with Et2O (4 ml) - this maybe resulted in slight loss of crystals but two or three larger (2-3 mm) crystals were fished out and dried under vacuum.
Re: Yb(OTf)3/BINOL catalysed asymmetric acyl-PS formation of KAB26-20 by Murray Robertson
1st August 2012 @ 03:06
Single crystal x-ray diffraction confirmed the crystals as (R)-BINOL