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24th July 2012 @ 12:49
START: Scheduled for 25/07/12


Hazard and Risk Assessment
HRA KAB26-17

Previous Experiments
Preparation of MNR42-1
Yb(OTf)3 (THF solution) catalysed acyl-PS formation of KAB26-16 in MeCN

Chemical Information
2-(3,4-dimethoxyphenyl)-N-(4-nitrobenzylidene)ethanamine (MNR42-1) - SMILES: O=[N+]([O-])C1=CC=C(/C=N/CCC2=CC(OC)=C(OC)C=C2)C=C1, InChI: InChI=1S/C17H18N2O4/c1-22-16-8-5-13(11-17(16)23-2)9-10-18-12-14-3-6-15(7-4-14)19(20)21/h3-8,11-12H,9-10H2,1-2H3/b18-12-, InChIKey: LMBMXYXQVBPKHJ-PDGQHHTCSA-N.
1-(6,7-dimethoxy-1-(4-nitrophenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (KAB26-17) - SMILES: O=[N+]([O-])C1=CC=C(C2N(C(C)=O)CCC3=CC(OC)=C(OC)C=C32)C=C1, InChI: InChI=1S/C19H20N2O5/c1-12(22)20-9-8-14-10-17(25-2)18(26-3)11-16(14)19(20)13-4-6-15(7-5-13)21(23)24/h4-7,10-11,19H,8-9H2,1-3H3, InChIKey: OIFIJKJQAGAGKY-UHFFFAOYSA-N.
2,6-bis((R)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine ((R)-PyBOX) - SMILES: CC([C@@H]1COC(C2=CC=CC(C3=N[C@H](C(C)C)CO3)=N2)=N1)C, InChI: InChI=1S/C17H23N3O2/c1-10(2)14-8-21-16(19-14)12-6-5-7-13(18-12)17-20-15(9-22-17)11(3)4/h5-7,10-11,14-15H,8-9H2,1-4H3/t14-,15-/m0/s1, InChIKey: CSGQGLBCAHGJDR-GJZGRUSLSA-N.

NOTE: All THF was dried over microwave activated 3 Å molecular sieves (2.0-2.5 mm) >72 h prior to use. All acetonitrile was dried over microwave 3 Å molecular sieves (2.0-2.5 mm) >24 h prior to use.[1] All glassware used was dried overnight at 115 °C.

2,6-Bis[(4R)-(+)-isopropyl-2-oxazolin-2-yl]pyridine (39 mg, 0.129 mmol, 2 equiv.) and Yb(OTf)3 (0.040 mg, 0.064 mmol, 1 equiv.) were dissolved in dried THF (1.9 mL) to give a chiral catalyst solution of 34 mM.

To a mixture of 3 Å molecular sieves (~1.5 g) in MeCN (16 mL) was dissolved MNR42-1 (100 mg, 0.318 mmol, 1 equiv.). The mixture was cooled in an acetone ice bath (-10 °C) before the addition of acetyl chloride (0.04 mL, 0.6 mmol, 1.8 equiv.) and 2,6-lutidine (0.06 mL, 0.5 mmol, 1.6 equiv.). The catalyst solution (0.47 mL, 0.016 mmol, 0.05 equiv.) was added. The reaction mixture was allowed to warm to 25 °C and stirred under argon from 09:30.
After 2 hours, the reaction mixture was diluted with EtOAc (15 mL). The mixture was washed with saturated sodium bicarbonate solution (15 mL). The organic layer was separated. The aqueous layer was extracted with EtOAc (3 × 15 mL). The organic layers were combined, dried (MgSO4) and concentrated under reduced pressure to yield crude KAB26-17.

Catalyst Solution Preparation

Summary and Conclusion

[1] D. Bradley, G. Williams and M. Lawton, J. Org. Chem. 2010, 75, 8351. DOI: 10.1021/jo101589h Paper.
[2] H. C. Aspinall, J. F. Bickley, N. Greeves, R. V. Kelly and P. M. Smith, Organometallics 2005, 24, 3458. DOI: 10.1021/om050197+ Paper.
[3] H. Suga, K. Inoue, S. Inoue, A. Kakehi and M. Shiro, J. Org. Chem. 2005, 70, 47. DOI: 10.1021/jo049007f Paper
[4] Rare-Earth Metal Triflates in Organic Synthesis, S. Kobayashi, M. Sugiura, H. Kitagawa and W. W.-L. Lam, Chem. Rev. 2002, 102, 2227–2302. DOI: 10.1021/cr010289i Paper.

Linked Posts
Attached Files
HRA KAB26-17
Scheme KAB26-17
Table KAB26-17
Scheme KAB26-17 (corrected)