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Pictet-Spengler route to Praziquantel
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10th July 2012 @ 09:21

4-Nitrobenzaldehyde (5.37 g, 35.53 mmol) was suspended in diethyl ether (45 mL). 3,4-Dimethoxyphenylethanamine (6.0 mL, 35 mmol) was added dropwise, with stirring. The mixture was left to stir at ambient temperature for 6 hours and concentrated under reduced pressure.

Recrystallisation of the crude product from ethanol (170 mL) afforded the pure product as yellow needles.

10.954 g, 34.84 mmol, 98 %

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