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4th July 2012 @ 10:37
Synthesis of MNR40-3 - same reaction time as MNR40-1 but using reagents straight from the bottle and no molecular sieves

MNR41-4%20scheme.png

HIRAC
HIRAC MNR41.pdf


Procedure

To a solution of KAB23-2 (0.10 g, 0.32 mmol) in acetonitrile (10 mL, HPLC grade) was added was added acetyl chloride (0.02 mL, 0.32 mmol) and 2,6-lutidine (0.04 mL, 0.32 mmol). Yb(OTf)3 (0.01 g, 0.02 mmol, 0.05 equiv) was added and the reaction was stirred at ambient temperature (~15 °C) for XX hours.

Mixture was clear then upon adding the AcCl the mixture turned yellow, then on adding the 2,6-lutidine the mixture went clear again. Reaction not under nitrogen or argon but flask sealed.

The reaction was never worked up or taken forward due to future reactions taking priority