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6th February 2012 @ 00:54
MNR12-5%20scheme.png

MNR12-5%20table.PNG

Hazard and Risk Assessment:

Procedure:

To a stirring solution of MNR10-2 (15.5 g, 38.8 mmol) in toluene (500 mL) at 0 °C was added a solution of TfOH (1.5 mL, 16.90 mmol) in toluene (35 mL) drop-wise via cannula. The reaction was then stirred at 0 °C for 90 minutes then allowed to reach room temperature and stirred for a further 1 hour. As the reaction proceeded it turned a darker shade of yellow to orange.

The reaction was neutralised with saturated sodium hydrogen carbonate and the aqueous layer was separated then washed with EtOAc (200 ml x 3). The organic fractions were combined, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give a dark red oil.

Crude:- 15.05 g
Attached Files
MNR12-5 table.PNG
MNR12-5 scheme.png