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31st January 2012 @ 23:47
MNR8-3%20scheme.png
MNR8-3%20table.PNG

Hazard and Risk Assessment:

As for MNR8-1

Procedure:

To a stirring suspension of paraformaldehyde (0.63 g, 21.0 mmol), 2,2-dimethoxyethylamine (3.04 mL, 21.0 mmol) and cyclohexanecarboxylic acid (2.60 mL, 21.0 mmol) in methanol (20 mL) at 0 °C was added 2-(3,4-Dimethoxyphenyl)ethyl isocyanide MNR4-2 (4.0 g, 21.0 mmol) dropwise and stirred at room temperature for 22 hours.

The reaction was concentrated and dissolved in EtOAc (50 mL) then washed with water (25 mL) and brine (25 mL) then dried over magnesium sulfate, filtered and concentrated under reduced pressure to give the crude as a pale yellow oil.

Crude :- 8.056 g

Column :- 40-66 % EtOAc/Hex

Frac 9-40
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MNR8-3 scheme.png
MNR8-3 table.PNG
MNR8-3 table.PNG
mnr8-3_frac_9-40.pdf
mnr8-3_frac_9-40.zip