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9th June 2010 @ 03:48
Preparation of starting material for the Ugi reaction

Hazard and Risk Assessment:
Reaction Class: 2
Hazards: T Toxic, X Irritant, C Corrosive
Risk rating: U = Unlikely

Start time: 11:05 AM 09/06/2010
End time: --

To a mixture of phenethylamine (1.00 g, 8.25 mmol), benzyltriethylammonium chloride (TEBACl) (94 mg, 413 µmol, 5 mol%) and NaOH (1.32 g, 33.0 mmol, 4 eq.) in DCM (20 mL) was added chloroform (1.48 g, 1.0 mL, 12.4 mmol, 1.5 eq.) and heated to reflux.

References:
[1] “Novel Synthesis of Praziquantel“, A. Dömling, Patent Application 2009, WO 2009/11533(A1), Language: German.
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Reaction Scheme
Table1