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24472491Acid-mediated Pictet-Spengler of MW51 to give N-benzoyl-derivative of PZQ MNR14-1
Experiments
www.google.com-accounts-o8-id-id=AItOawmHgL4uOJCXiVgu09ud3WRBjgfQtBatmNEMurray Robertson [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2422/Acidmediated_PictetSpengler_of_MNR82_to_give_dimethoxyNbenzoylderivative_of_PZQ_MNR122.html]MNR12-2[/url] [b]Procedure[/b] MW51 (95 mg, 0.28 mmol) was stirred with methanesulfonic acid (1.82 mL, 28 mmol) at room temperature and after 1 hour (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 60 mg as a yellow oil that showed signs of slowly crystallizing after 24 hours]]>




Hazard and Risk Assessment:
As for MNR12-2

Procedure
MW51 (95 mg, 0.28 mmol) was stirred with methanesulfonic acid (1.82 mL, 28 mmol) at room temperature and after 1 hour (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 60 mg as a yellow oil that showed signs of slowly crystallizing after 24 hours
Linked Posts
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24476986Acid-mediated Pictet-Spengler of MW51 to give N-benzoyl-derivative of PZQ MNR14-1
Experiments
www.google.com-accounts-o8-id-id=AItOawmHgL4uOJCXiVgu09ud3WRBjgfQtBatmNEMurray Robertson [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2422/Acidmediated_PictetSpengler_of_MNR82_to_give_dimethoxyNbenzoylderivative_of_PZQ_MNR122.html]MNR12-2[/url] [b]Procedure[/b] MW51 (95 mg, 0.28 mmol) was stirred with methanesulfonic acid (1.82 mL, 28 mmol) at room temperature and after 1 hour (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 60 mg as a yellow oil that showed signs of slowly crystallizing after 24 hours]]>




Hazard and Risk Assessment:
As for MNR12-2

Procedure
MW51 (95 mg, 0.28 mmol) was stirred with methanesulfonic acid (1.82 mL, 28 mmol) at room temperature and after 1 hour (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 60 mg as a yellow oil that showed signs of slowly crystallizing after 24 hours
Linked Entries
This entry is linked by:
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