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6th October 2011 @ 23:52
Repeat of MNR12-1 but at 60°C

MNR12-2%20scheme.png

MNR12-2%20table.PNG

Hazard and Risk Assessment:
HIRAC MNR12.pdf


Procedure:
MNR8-2 (130 mg, 0.28 mmol) was stirred with methanesulfonic acid (1.8 mL, 28 mmol) at 60°C and after 1 hour (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 72 mgs as an orange oil
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Attached Files
MNR12-2 table.PNG
MNR12-2 scheme.png
HIRAC MNR12.pdf