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24212490Acid-mediated Pictet-Spengler of MNR8-2 to give dimethoxy-N-benzoyl-derivative of PZQ MNR12-1
Experiments
www.google.com-accounts-o8-id-id=AItOawmHgL4uOJCXiVgu09ud3WRBjgfQtBatmNEMurray Robertson [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2422/Acidmediated_PictetSpengler_of_MNR82_to_give_dimethoxyNbenzoylderivative_of_PZQ_MNR122.html]MNR12-2[/url] [b]Procedure[/b] MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 112 mgs as an orange oil that slowly crystallised over the weekend.]]>MW54-3





Hazard and Risk Assessment:
As for MNR12-2

Procedure
MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 112 mgs as an orange oil that slowly crystallised over the weekend.
Linked Posts
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24216952Acid-mediated Pictet-Spengler of MNR8-2 to give dimethoxy-N-benzoyl-derivative of PZQ MNR12-1
Experiments
www.google.com-accounts-o8-id-id=AItOawmHgL4uOJCXiVgu09ud3WRBjgfQtBatmNEMurray Robertson [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2422/Acidmediated_PictetSpengler_of_MNR82_to_give_dimethoxyNbenzoylderivative_of_PZQ_MNR122.html]MNR12-2[/url] [b]Procedure[/b] MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 112 mgs as an orange oil that slowly crystallised over the weekend.]]>MW54-3





Hazard and Risk Assessment:
As for MNR12-2

Procedure
MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 112 mgs as an orange oil that slowly crystallised over the weekend.
Linked Entries
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