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24192440Acid-mediated Pictet-Spengler of MNR8-2 to give dimethoxy PZQ analog MNR11-2
Experiments
www.google.com-accounts-o8-id-id=AItOawmHgL4uOJCXiVgu09ud3WRBjgfQtBatmNEMurray Robertson [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2403/Acidmediated_PictetSpengler_of_MNR81_to_give_dimethoxy_PZQ_analog_MNR111.html]MNR11-1[/url] [b]Procedure:[/b] MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 67 mgs as an off white foam (almost crystalline)]]>




Hazard and Risk Assessment:
As for MNR11-1

Procedure:
MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 67 mgs as an off white foam (almost crystalline)
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24196942Acid-mediated Pictet-Spengler of MNR8-2 to give dimethoxy PZQ analog MNR11-2
Experiments
www.google.com-accounts-o8-id-id=AItOawmHgL4uOJCXiVgu09ud3WRBjgfQtBatmNEMurray Robertson [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2403/Acidmediated_PictetSpengler_of_MNR81_to_give_dimethoxy_PZQ_analog_MNR111.html]MNR11-1[/url] [b]Procedure:[/b] MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 67 mgs as an off white foam (almost crystalline)]]>




Hazard and Risk Assessment:
As for MNR11-1

Procedure:
MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude - 67 mgs as an off white foam (almost crystalline)
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