All Notebooks | Help | Support | About
6th October 2011 @ 23:47
Repeat of MNR11-1 but at room temperature [b]Hazard and Risk Assessment:[/b] As for [url=http://www.ourexperiment.org/racemic_pzq/2403/Acidmediated_PictetSpengler_of_MNR81_to_give_dimethoxy_PZQ_analog_MNR111.html]MNR11-1[/url] [b]Procedure:[/b] MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Crude - 67 mgs as an off white foam (almost crystalline)
Attached Files
MNR11-2 scheme.png
MNR1-2 table.PNG
MNR11-2 table.PNG