Notice: Undefined index: showqr in /home/www/hosts/www.ourexperiment.org/lib/proc_blog.php on line 33
Pictet-Spengler route to Praziquantel
All Notebooks | Help | Support | About
28th September 2011 @ 01:44

Hazard and Risk Assessment:

HIRAC MNR11.pdf

Procedure:MNR8-1 (80 mg, 0.22 mmol) was stirred with methanesulfonic acid (1.4 mL, 22 mmol) at 60°C and after 3 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

Crude proton NMR showed what looked like product and the loss of key starting material peaks.

mnr11-1_crude.pdf

FCC EtOAc/Hexane (50-80%).

Frac 27-28:- 0.037 g, 0.1 mmol, 58 % as a white gummy oil.

mnr11-1_frac27-38.pdf
mnr11-1.zip

 

IR 

1b rac IR MNR11-1.jpg

Lab book page complete, MNR

Linked Entries
This entry is linked by:
Attached Files
MNR11-1 scheme.png
MNR11-1 table.PNG
HIRAC MNR11.pdf
mnr11-1_crude.pdf
mnr11-1_frac27-38.pdf
mnr11-1_20-26.zip
mnr11-1.zip
kab1-2 1H 500.pdf
kab1-2 13C 500.pdf
kab1-2.zip
1b rac IR MNR11-1.jpg