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Pictet-Spengler route to Praziquantel
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Comments
Re: Acid-catalyzed Pictet-Spengler reaction with binaphthalenedisulfonic acid (MW56-1 to MW56-4) by Matthew Todd
15th March 2011 @ 10:14
That's odd. No reaction at all? I'd expect the acetal to go, even if the cyclization does not. Your follow-up reaction with MeSO3H is the right thing to do, yes.