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17th February 2011 @ 08:19
Attempts to the acid-mediated cyclization of the N-benzoyl-protected Ugi intermediate MW51-1 with methanesulfonic acid

See also:
Attempts to the Bronstedt-acid catalysed Pictet-Spengler cyclization using BINOL-N-triflyl phosphoramide (MW41)
Cleavage of the dimethoxy acetal of 2-((2,2-dimethoxyethyl)amino)-N-phenethylacetamide hydrochloride MW7(MW42)

Reaction Scheme


Hazard and Risk Assessment:
HRAF MW53.pdf


Start time: 7:30 PM 17/02/2011
End time: --

MW53-1:
MW51-1 (31 mg, 83.8 ┬Ámol, M.W. 370.4 g/mol) was stirred with methanesulfonic acid (0.5 mL) for xx h at room temperature.

MW53-2:
MW51-1 (29 mg, 78.4 ┬Ámol, M.W. 370.4 g/mol) was stirred with formic acid (0.5 mL) for xx h at room temperature.
Linked Posts
Attached Files
Reaction Scheme
HRAF MW53.pdf
1H NMR MW53-1.pdf