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Racemization of PZQ and PZQamine
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7th April 2011 @ 09:37
Racemization experiments on [url=] (R)-(-)-PZQ[/url] with Rhodium on charcoal [data=size:500x180]1039[/data] See also: [*] [url=]Experiments on the racemization of (R)-PZQ (MW55-1 to MW55-3)[/url] [*] [url=]Experiments on the racemization of (R)-PZQ with Raney Nickel (MW55-4)[/url] [*] [url=]Racemization of S-(+)-PZQamine (MW50-9) and (R) -(-)-PZQ (MW55-5) with sodium naphthalide[/url] [*] [url=]Repetition: Racemization of S-(+)-PZQamine (MW50-10) and R -(-)-PZQ (MW55-6) with sodium naphthalide[/url] [*] [url=]Racemization of S-(+)-PZQamine with Raney Nickel under high pressure and high temperature (MW50-11)[/url] [b]Hazard and Risk Assessment:[/b] [data]735[/data] Start time: 7:00 PM 7/04/2011 End time: 10:00 AM 11/04/2011 To a solution of [url=](R)-(-)-PZQ[/url] (20.0 mg, 64.0 µmol) in toluene (2 mL) was added Rhodium/Charcoal (6.6 mg, 6.40 µmol, 0.1 eq.; 10% Rh on C, M.W. (Rh) 102.9 g/mol) and heated to 70°C for 4 d. Chiral HPLC (Chiralcel OD-H, hexane/iso-propanol/Et3N = 60/40/0.1, 0.7 ml/min flow rate): RT: (R)-PZQ: 12.4 min, (S)-PZQ: 15.0 min [data]1050[/data][data]1053[/data] [b]-> no racemization[/b]
Attached Files
Scheme MW50-8 PZQ.png
HPLC MW55-8.jpg
HPLC MW55-8 + rac-PZQ.jpg