Notice: Undefined index: NAME in /home/www/hosts/www.ourexperiment.org/lib/functions_blog.php on line 123

Notice: Undefined index: NAME in /home/www/hosts/www.ourexperiment.org/lib/functions_blog.php on line 123
Racemization of PZQ and PZQamine
All Notebooks | Help | Support | About
7th April 2011 @ 09:37
Racemization experiments on (R)-(-)-PZQ with Rhodium on charcoal

Scheme MW50-8 PZQ.png


See also:
Experiments on the racemization of (R)-PZQ (MW55-1 to MW55-3)
Experiments on the racemization of (R)-PZQ with Raney Nickel (MW55-4)
Racemization of S-(+)-PZQamine (MW50-9) and (R) -(-)-PZQ (MW55-5) with sodium naphthalide
Repetition: Racemization of S-(+)-PZQamine (MW50-10) and R -(-)-PZQ (MW55-6) with sodium naphthalide
Racemization of S-(+)-PZQamine with Raney Nickel under high pressure and high temperature (MW50-11)

Hazard and Risk Assessment:
HRAF MW50.pdf


Start time: 7:00 PM 7/04/2011
End time: 10:00 AM 11/04/2011

To a solution of (R)-(-)-PZQ (20.0 mg, 64.0 µmol) in toluene (2 mL) was added Rhodium/Charcoal (6.6 mg, 6.40 µmol, 0.1 eq.; 10% Rh on C, M.W. (Rh) 102.9 g/mol) and heated to 70°C for 4 d.

Chiral HPLC (Chiralcel OD-H, hexane/iso-propanol/Et3N = 60/40/0.1, 0.7 ml/min flow rate): RT: (R)-PZQ: 12.4 min, (S)-PZQ: 15.0 min
HPLC MW55-8.jpg
HPLC MW55-8 + rac-PZQ.jpg


-> no racemization
Attached Files
Scheme MW50-8 PZQ.png
HPLC MW55-8.jpg
HPLC MW55-8 + rac-PZQ.jpg