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21st June 2012 @ 02:04
MNR37-1%20scheme.png
mnr37-2%20table.PNG

Hazard and Risk Assessment:
HIRAC MNR37.pdf


Procedure:
A mixture of rac-PZQ (10.0 g, 32.0 mmol) and sulfur (2.1 g, 64.0 mmol) under argon was heated at 190°C for 15 minutes by use of a heat gun. The mixture was then allowed to cool and diluted with DCM and EtOAc (100 mL) (probelems getting everything into solution, some white solid left behind). Silica was added and the solvent was evaporated and purified by column chromatography (25% EtoAC/Hex)

Frac 1-6
Frac 7-8 - attempted re-cryst with toluene
Frac 9-12
Attached Files