All Notebooks | Help | Support | About
28th January 2014 @ 22:28
Reaction proceeded as expected. Product was obtained in 87% yield.

START: 28/01/14
FINISH: 31/01/14

Scheme
scheme_KAB119-1.png

Hazard and Risk Assessment
HNMR KAB119-1 300 MHz CDCl3


Procedure
28/01/14. Suspended KAB8-17 in ethanol and HCl (1 M). Heated to reflux from 1500; oil bath approx. 130 ° C. Yellowish heterogenous solution.

29/01/14. 0800, clear mixture homogenous and orange. Allowed to cool. Basified to pH 11-13 using solid KOH (about 4 g). Extracted with dichloromethane (2 × 100 mL) and ethyl acetate (100 mL). Combined organic fractions were dried with Na2SO4, concetrated under reduced pressure and dried in vacuo to give an orange solid (1.49 g, 87%)

HNMR consistent with the expected product. No purification required.

Raw HNMR KAB119-1 300 MHz CDCl3
HNMR KAB119-1 300 MHz CDCl3


--------------------------------------------
Linked Posts
Attached Files
Scheme KAB119-1
HNMR KAB119-1 300 MHz CDCl3
Raw HNMR KAB119-1 300 MHz CDCl3
HIRAC KAB119-1