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4th July 2012 @ 10:35
Synthesis of MNR40-2 - extended reaction reaction time compared to MNR40-1




To a solution of KAB23-2 (0.10 g, 0.32 mmol) in dry acetonitrile (10 mL, Sigma sure/seal) and 3 Å molecular sieves (2 g, dried in microwave) under argon, was added was added acetyl chloride (0.02 mL, 0.32 mmol) and 2,6-lutidine (0.04 mL, 0.32 mmol, stored over 3 Å molecular sieves). Yb(OTf)3 (0.01 g, 0.02 mmol, 0.05 equiv) was added and the reaction was stirred at ambient temperature (~15 °C) for 38 hours.

The reaction was not worked up or taken forward as future reactions took priority.