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21st June 2012 @ 01:21
MNR14-4%20scheme.png

Hazard and Risk Assessment:
As for MNR12-2

Procedure
MNR22-2 (frac 4-7) (9.0 g, 22.6 mmol) was stirred with methanesulfonic acid (73 mL, 1.1 mol) at room temperature and after 2 hours all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (300 mL x3). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.

The crude was then purified by FCC EtOAc/Hexane (50-100%)

Fracs 8-12