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5th June 2012 @ 09:59
Scale up of MNR11-16

Synthesis of MNR11-16

MNR11-1%20scheme.png

MNR11-17%20table.PNG

Hazard and Risk Assessment:
HIRAC MNR11.pdf


Procedure:
To a solution of MNR8-5 (8.30 g, 17.87 mmol) in toluene (60 mL) at room temperature was added methanesulfonic acid (2.49 mL, 38.41 mmol) and the mixture was refluxed for 30 minutes. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (50 mL x 3). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure to give the crude as a thick orange oil.

Crude - 7.071 g, 106 % - still contains toluene

mnr11-17_crude.pdf
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Attached Files
MNR11-17 table.PNG
mnr11-17_crude.pdf