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18th May 2012 @ 04:00
MNR11-15%20scheme.png

MNR8-5 (0.75 g, 1.61 mmol) in toluene (8 mL) was treated with methanesulfonic acid (0.01 mL, 1.61 mmol) and the reaction was stirred at room temperature for 5 hours by which time TLC had shown complete consumption of SM. The reaction was neutralised with sat. sodium hydrogen carbonate solution, the organic fraction extracted and the aqueous fraction was washed with EtOAc (10 mL x 3). The organic layers were combined, dried, filtered and concentrated to give a thick dark orange oil


TLC after 90mins still showed starting material
TLC 90 mins

TLC in 100% EtOAc, SM, Co, Rxn.

TLC after a total of 5 hours
MNR11-5 5 hours


Crude - 0.680 g
Attached Files
TLC 90 mins
MNR11-5 5 hours
MNR11-15 scheme.png