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Reducing reaction time and temperature of MW54-3
Hazard and Risk Assessment:
As for MNR12-2
Procedure
MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.
Crude - 112 mgs as an orange oil that slowly crystallised over the weekend.
Hazard and Risk Assessment:
As for MNR12-2
Procedure
MNR8-2 (120 mg, 0.26 mmol) was stirred with methanesulfonic acid (1.7 mL, 26 mmol) at room temperature and after 1 hours (first TLC) all the starting material had been consumed. The reaction was quenched with saturated sodium carbonate and extracted with EtOAc (20 mL x2). The organic fractions were dried over magnesium sulfate, filtered and concentrated under reduced pressure.
Crude - 112 mgs as an orange oil that slowly crystallised over the weekend.
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MNR12-1 scheme.png
MNR12-1 table.PNG